12 rationale for enhancing replication stress to cause cancer cell death the net effect of replicative stress is the stalling of replication forks and the accumulation of ssdna as previously described 134the ssdna is rapidly coated by ssdna binding proteins such as replication protein a rpa which then activates the atr signaling pathway resulting in the subsequent phosphorylation of . Catherine green professor catherine green leads the chromosome dynamics group at the wellcome trust centre for human genetics she studies dna replication forks where genome instability is likely to arise and can lead to cancer or other disorders. Dna sequencing lays foundation for personalized cancer treatment date april 1 2012 source washington university in st louis summary scientists are using powerful dna sequencing technology not . Complete and accurate dna replication is fundamental to cellular proliferation and genome stability obstacles that delay prevent or terminate dna replication cause the phenomena termed dna replication stress cancer cells exhibit chronic replication stress due to the loss of proteins that protect or repair stressed replication forks and due to the continuous proliferative signaling . Gene therapy is quite an innovative technology which is developing and advancing at a rapid pace the use of gene therapies to create new medical procedures which when used alone or in combination with the currently available treatment such as chemotherapy will be able to target cancer and make it a manageable disease
How it works:
1. Register a Free 1 month Trial Account.
2. Download as many books as you like ( Personal use )
3. No Commitment. Cancel anytime.
4. Join Over 100.000 Happy Readers.
5. That's it. What you waiting for? Sign Up and Get Your Books.